Warfarin

Warfarin
Systematic (IUPAC) name
	(RS)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)- 2H-chromen-2-one
Clinical data
Trade names	Coumadin, Jantoven, Marevan
Licence data	US FDA:link
Pregnancy cat.	AU: D; US: X;
Legal status	AU: Prescription Only (S4); CA: ℞-only; UK: POM; US: ℞-only;
Routes	Oral or intravenous
Pharmacokinetic data
Bioavailability	79-100% (Oral)
Protein binding	99%
Metabolism	Hepatic: CYP2C9, 2C19, 2C8, 2C18, 1A2 and 3A4
Half-life	20-60 hours (mean: 40 hours)
Excretion	Renal (92%)
Identifiers
CAS number	81-81-2Template:CasciteI
ATC code	B01AA03
PubChem	CID 54678486
DrugBank	DB00682
ChemSpider	10442445Template:Chemspidercite
UNII	5Q7ZVV76EITemplate:Fdacite
KEGG	D08682Template:Keggcite
ChEBI	CHEBI:10033 Template:Tick
ChEMBL	CHEMBL1464 Template:Tick
Chemical data
Formula	C19H16O4
Mol. mass	308.33 g/mol
	SMILES CC(=O)CC(C\1=C(/O)c2ccccc2OC/1=O)c3ccccc3;
	InChI InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3 Template:Tick; Key:PJVWKTKQMONHTI-UHFFFAOYSA-N Template:Tick;
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↑ Holford, NH: [http://link.springer.com/article/10.2165%2F00003088-198611060-00005 Clinical Pharmacokinetics and Pharmacodynamics of Warfarin Understanding the Dose-Effect Relationship.] In: Springer International Publishing (Hrsg.): Clinical Pharamacokinetics. 11, Nr. 6, December 1986, S. 483-504. Script error: No such module "Vorlage:Handle".. PMID 3542339.
1 2 3 4 "PRODUCT INFORMATION COUMADIN" (PDF). TGA eBusiness Services. Aspen Pharma Pty Ltd. 19 January 2010. Retrieved 11 December 2013.